12/2/2023 0 Comments Statins and grapefruit beerJust as each individual has a unique fingerprint and DNA profile, each has a unique P450 profile. But these foods’ effects are far from uniform. While grapefruit juice and the compounds it contains are among the most extensively studied foods and beverages for their effects on the metabolism and action of prescription drugs, recent research has found that other foods, including pomegranates, Seville oranges, black pepper, cranberry juice, grape juice, black tea, beer, cruciferous vegetables, kava, licorice root, wine, and olive oil, contain compounds that modulate P450 activity and can affect drug metabolism. Researchers with Health Canada found that many phytochemical constituents in natural health products have the potential to significantly alter the bioavailability, absorption, distribution, and excretion of prescription drugs in the same way as foods by interfering with drug-metabolizing enzyme systems.2 The same is true for many natural health products. Generally, foods can either interfere with the body’s ability to absorb a medication, reducing the dose actually received, or they can increase absorption, which can improve availability of the drug or pose the risk of toxicity. “A food effect can be positive or negative, and it can be quite significant,” said Rebecca Carrier, PhD, an assistant professor in the department of chemical engineering at Northeastern University in Boston, during a symposium on food-drug interactions at the American Chemical Society meeting in Boston earlier this year. Older patients are particularly at risk for negative food and drug interactions simply because this population takes more than 30% of all prescription drugs.1 Patients with cancer and/or malnutrition, gastrointestinal tract dysfunction, or acquired immunodeficiency syndrome patients receiving enteral nutrition and transplant recipients are also at risk.1 But thanks to the discovery a little more than a decade ago that grapefruit juice contains powerful natural compounds that interfere with the cytochrome P450 enzyme system, or enzymes in the liver responsible for metabolizing about 50% of drugs currently prescribed1, food-drug interactions have been garnering more attention, and researchers are asking and answering more questions about the roles that foods play in drug metabolism.Ī food-drug interaction is the alteration of a drug’s pharmacokinetics or pharmacodynamics when certain foods or beverages are consumed at the same time. They also know that the calcium in dairy products can interfere with the availability of some antibiotics. When Foods and Drugs Collide - Studies Expose Interactions Between Certain Foods and Medicationsĭietitians, physicians, and pharmacists have long known that some drugs are absorbed well on an empty stomach and others with food.
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